Hematopoietic-supportive effect of （2S,3R）-ent-catechin on marrow-depressed mice

Hematopoiesis is an active process of cell proliferation, differentiation and release. It is the process during which hematopoietic stem cells (HSCs) proliferate and differentiate to mature blood cells under the effect of hemetopoietic growth factors (HGFs) in certain hematopoietic microenvironment. HSCs are sources of hematopoiesis of a body that can self-renew, differentiate to blood cells of every lineage and maintain the constancy of them. As the major tissue of hematopoiesis bone marrow is filled with all kinds of blood cells in various developmental stages. Under the normal conditions, the ordered proliferation and differentiation of hematopoietic stem cells/hematopoietic progenitor cells (HSC/HPC) depend on the regulation of cytokine network.

完成机构：[1]InstituteofMateriaMedica,ChineseAcademyofMedicalSciencesandPekingUnionMedicalCollege,Beijing100050,China [2]ResearchInstituteforClinicaiPharmacology,GeneralHospitalofPLA,Beijing100853,China